Mean absolute thickness of the tibial and femoral articular cartilage regions as a function of loading. Unloaded (δ0) and loaded to 7.5 kp (δvar1, δvlg1), 15 kp (δvar2, δvlg2), and 22.5 kp (δvar3, δvlg3). Mean ± standard deviations (mm) (mean percentage change versus δ0 (%)). Values are given for the loaded compartment only, i.e., the medial compartment under varus loading and the lateral compartment under valgus loading. Statistical analysis was performed using repeated measures ANOVA with statistically significant findings highlighted in bold type.