Table 1.
Recent clinical trials for attenuated scar skin repair (completed phase III or ongoing).
| Treatment (Mechanism) | Type of Skin Fibrosis | Phase Status | ClinicalTrials.gov ID |
|---|---|---|---|
| Rituximab/CD20 mAb (immunomodulation) | Scleroderma, SSc | Phase II/III (2019) | NCT04274257 |
| FS2/kynurenic acid (immunomodulation) |
Scar, hypertrophic scar, graft scar, keloid | Phase II (ongoing) | NCT04186273 |
| Pirfenidone (unknown mechanism) |
Scar | Phase II/III (ongoing) |
NCT03068234 |
| Pentoxifylline, vitamin E (ECM remodelling) |
Postoperative radiation-induced fibrosis | Phase III (ongoing) | NCT02898376 |
| Fractional CO2 laser (ECM remodelling) |
Scar, burns, graft scars | N/A (ongoing) | NCT04456127 |
| Integra skin substitute (scar resection and healing) |
Scar | N/A (ongoing) | NCT04420442 |
| Autologous cell dermal scaffolds (scar resection and healing) |
Scar, hypertrophic scar | N/A (ongoing) | NCT04389164 |