Table 1.
Characteristics of patients in the entire cohort and subgroups.
| Variables | Study Cohort n = 186 (%) |
≤2 Lines of Therapy n = 102 (54.8%) (%) |
≥3 Lines of Therapy n = 84 (45.2%) (%) |
p Value |
|---|---|---|---|---|
| Demographics | ||||
| Median age | 63.5 (IQR: 54.0–74.0) | 67 (56.7–77.3) | 60 (51.0–68.0) | 0.001 |
| >50 years | 157 (84.4) | 93 (91.2) | 64 (76.2) | 0.007 |
| Rural residence | 94 (50.5) | 53 (52) | 41 (48.8) | 0.76 |
| Comorbid illness | 94 (50.5) | 58 (57) | 36 (42.8) | 0.24 |
| Secondary cancer | 22 (11.8) | 14 (13.7) | 8 (9.5) | 0.49 |
| WHO performance status 0–1 | 151 (81.2) | 82 (80.3) | 69 (82.1) | 0.85 |
| Smoking History | 69 (37.1) | 44 (43.1) | 25 (29.8) | 0.21 |
| History of early-stage breast cancer | 150 (80.6) | 85 (83.3) | 65 (77.4) | 0.35 |
| Bilateral breast cancer | 12 (8.0) | 10 (11.7) | 2 (3.0) | 0.12 |
| Surgery for early-stage breast cancer | ||||
| Mastectomy | 94 (62.6) | 53 (62.3) | 41 (63.0) | 0.37 |
| Lumpectomy | 36 (24.0) | 19 (22.3) | 17 (26.1) | 0.70 |
| Bilateral mastectomy | 20 (13.3) | 13 (15.3) | 7 (10.7) | 0.33 |
| Stage of early-breast cancer | ||||
| I | 35 (23.3) | 18 (21.1) | 17 (26.1) | 0.55 |
| II | 71 (47.3) | 40 (47.0) | 31 (47.8) | 1.0 |
| III | 44 (29.3) | 27 (31.7) | 17 (26.1) | 0.47 |
| Received Adjuvant therapy | 134 (89.3) | 75 (88.2) | 59 (90.7) | 0.79 |
| Adjuvant chemotherapy | 81 (54.0) | 44 (51.7) | 37 (56.9) | 0.62 |
| Adjuvant endocrine therapy | 110 (73.3) | 67 (78.8) | 43 (66.2) | 0.09 |
| Adjuvant radiation therapy | 96 (64.0) | 53 (62.4) | 43 (66.2) | 0.73 |
| Diagnosis of metastatic disease | ||||
| Clinical | 39 (21.0) | 30 (29.4) | 9 (10.7) | 0.002 |
| Pathological | 147 (79.0) | 72 (70.6) | 75 (89.3) | 0.004 |
| Receptor status | ||||
| Estrogen receptor positive | 183 (98.4) | 100 (98.0) | 83 (98.8) | 1.0 |
| Progesterone receptor positive | 152 (81.7) | 84 (82.4) | 68 (81.0) | 0.85 |
| HER2 overexpression | 17 (9.1) | 7 (6.9) | 10 (12.3) | 0.30 |
| Visceral metastases | 107 (57.5) | 53 (52.0) | 54 (64.3) | 0.10 |
| Location of Metastases | ||||
| Bone | 143 (76.9) | 75 (73.5) | 68 (81.0) | 0.29 |
| Lung | 78 (40.9) | 39 (38.2) | 39 (46.4) | 0.29 |
| Liver | 58 (31.2) | 27 (26.5) | 31 (36.9) | 0.15 |
| Skin or soft tissue | 47 (25.3) | 22 (21.6) | 25 (29.8) | 0.23 |
| Nodal | 27 (14.5) | 10 (9.8) | 17 (20.2) | 0.06 |
| Brain | 7 (3.8) | 2 (2.0) | 5 (6.0) | 0.24 |
| Peritoneal | 5 (2.7) | 3 (2.9) | 2 (2.4) | 1.0 |