Table 2.
Treatment information and response to fulvestrant.
| Variables | Study Cohort n = 186 (%) |
≤2 Lines of Therapy n = 102 (54.8%) (%) |
≥3 Lines of Therapy n = 84 (45.2%) (%) |
p Value |
|---|---|---|---|---|
| Median line of therapy | 2 (range 0–8) | 1 (0–2) | 4 (3–8) | <0.001 |
| Four or more lines of therapy | 42 (22.5) | 0 | 56 (71.8) | <0.001 |
| Median time from diagnosis to start of fulvestrant | 34 (IQR: 20.0–63.0) | 24.5 (12.0–44.5) | 44 (28.0–87.0) | 0.002 |
| Received chemotherapy prior to fulvestrant | 80 (43.0) | 18 (17.6) | 62 (73.8) | 0.001 |
| Combination treatment | 34 (18.3) | 21 (20.6) | 13 (15.5) | 0.44 |
| Targeted Therapy | 33 (17.7) | 21 (100) | 12 (92) | 0.32 |
| Endocrine Resistance | 178 (95.7) | 95 (93.1) | 83 (98.8) | 0.07 |
| Primary | 39 (21.9) | 27 (28.4) | 12 (14.4) | 0.04 |
| Reason for discontinuation of fulvestrant | ||||
| Progression | 139 (74.7) | 71 (69.6) | 68 (81.0) | 0.09 |
| Side effects or patient request | 19 (10.2) | 13 (12.7) | 6 (7.2) | 0.23 |
| Others | 3 (1.6) | 2 (1.9) | 1 (1.3) | 1.0 |
| Best Response to fulvestrant | ||||
| Complete response | 2 (1.1) | 2 (1.9) | 0 | 0.50 |
| Partial response | 24 (12.9) | 14 (13.8) | 10 (11.9) | 0.82 |
| Stable disease | 106 (57) | 65 (63.7) | 41 (48.8) | 0.05 |
| Progressive disease | 53 (28.6) | 21 (20.6) | 32 (38.1) | 0.009 |
| Unknown | 1 (0.5) | 0 | 1 (1.2) | 0.45 |
| Received chemotherapy post fulvestrant | 112 (60.2) | 57 (55.9) | 55 (65.5) | 0.22 |