Table 1.
Comparison of serum and urinary bone and mineral metabolism-related parameters, measured before PTX or in PHPT patients who did not undergo PTX, between MEN1 PHPT and sPHPT.
| Parameter 1 | MEN1 PHPT (n = 133) |
sPHPT (n = 47) |
p Value MEN1 PHPT vs. sPHPT |
|---|---|---|---|
| Age at measurement (years) | 38.9 ± 16.1 | 64.3 ± 14.1 | <0.01 |
| Parathyroid hormone (1.3–7.6 pmol/L) | 17.2 ** ± 17.2 | 19.0 ** ± 18.0 | Not significant |
| Serum calcium ion (4.3–5.3 mg/dL) | 5.67 ** ± 0.43 | 5.55 ** ± 0.35 | Not significant |
| Total serum calcium (8.5–10.1 mg/dL) | 10.5 ** ± 1.5 | 10.3 ** ± 0.9 | Not significant |
| Serum phosphate (2.5–4.9 mg/dL) | 2.5 ± 0.6 | 2.7 ± 0.3 | <0.01 |
| 25-hydroxy-vitamin D (30–100 ng/mL) | 21.7 * ± 11.6 | 33.7 ± 11.2 | <0.01 |
| Bone alkaline phosphatase (Men: 7–20 µg/L; pre-menopausal women: 4–14.3 µg/L; post-menopausal women: 6–22.5 µg/L) |
24.1 ** ± 14.1 | 17.2 ± 7.4 | <0.05 |
| Urinary calcium (42–353 mg/24 h) | 328.7 ± 155.4 | 269.5 ± 123.7 | Not significant |
| Urinary phosphate (400–1300 mg/24 h) | 780.3 ± 286.9 | 641.4 ± 210.3 | <0.05 |
| Urinary deoxypyridinoline (3.0–5.4 mnol/mmol creatinine) | 7.5 ** ± 3.7 | 7.3 ** ± 3.1 | Not significant |
| Nephrolithiasis | 63/133 (47.4%) | 15/47 (31.9%) | Not significant |
1 = normal values are indicated within brackets. * indicates a parameter value less than the normal range; ** indicate a parameter value higher than the normal range. The statistical significance (p value) is indicated in bold.