Table 2.
Comparison of serum and urinary bone and mineral metabolism-related parameters, measured before and after PTX, in MEN1 PHPT patients.
| Parameter 1 | Pre-Surgery MEN1 PHPT (n = 105) |
Post-Surgery MEN1 PHPT (n = 105) |
p Value Pre-Surgery vs. Post-Surgery |
Mean Percentage Change between Pre-Surgery and Post-Surgery Values |
|---|---|---|---|---|
| Age at measurement (years) | 34.4 ± 14.0 | 36.4 ± 13.8 | Non applicable | Non applicable |
| Gap between measurement and surgery (months) | 5.3 ± 5.2 | 12.41 ± 12.8 | Non applicable | Non applicable |
| Parathyroid hormone (1.3–7.6 pmol/L) | 20.0 ** ± 19.7 | 5.2 ± 3.3 | <0.01 | −64.6 ± 29.7% |
| Serum calcium ion (4.3–5.3 mg/dL) | 5.84 ** ± 0.41 | 4.88 ± 0.50 | <0.01 | −16.0 ± 10.7% |
| Total serum calcium (8.5–10.1 mg/dL) | 10.7 ** ± 0.9 | 9.0 ± 0.8 | <0.01 | −15.0 ± 11.1% |
| Serum phosphate (2.5–4.9 mg/dL) | 2.3 * ± 0.5 | 3.0 ± 0.5 | <0.01 | +37.9 ± 33.4% |
| 25-hydroxy-vitamin D (30–100 ng/mL) | 17.4 * ± 8.0 | 30.0 ± 15.3 | <0.01 | +97.8 ± 117.0% |
| Bone alkaline phosphatase (Men: 7–20 µg/L; pre-menopausal women: 4–14.3 µg/L; post-menopausal women: 6–22.5 µg/L) |
29.3 ** ± 17.1 | 18.5 ± 12.2 | <0.05 | −25.5 ± 65.1% |
| Urinary calcium (42–353 mg/24 h) | 353.4 ** ± 124.1 | 210.4 ± 89.3 | <0.01 | −24.9 ± 74.1% |
| Urinary phosphate (400–1300 mg/24 h) | 755.3 ± 205.1 | 768.4 ± 262.2 | Not significant | +11.6 ± 51.9% |
| Urinary deoxypyridinoline (3.0–5.4 mnol/mmol creatinine) | 8.9 ** ± 3.1 | 5.9 ** ± 1.5 | <0.01 | −29.8 ± 19.4% |
1 = normal values are indicated within brackets. * indicates a parameter value less than the normal range; ** indicate a parameter value higher than the normal range. The statistical significance (p value) is indicated in bold.