Table 3.
Comparison of serum and urinary bone and mineral metabolism-related parameters, measured before and after PTX, in sPHPT patients.
| Parameter 1 | Pre-Surgery sPHPT (n = 29) |
Post-Surgery sPHPT (n = 29) |
p Value Pre-Surgery vs. Post-Surgery |
Mean Percentage Change between Pre-Surgery and Post-Surgery Values |
|---|---|---|---|---|
| Age at measurement (years) | 58.2 ± 13.7 | 59.2 ± 13.1 | Non applicable | Non applicable |
| Gap between measurement and surgery (months) | 5.4 ± 3.6 | 7.2 ± 10.3 | Non applicable | Non applicable |
| Parathyroid hormone (1.3–7.6 pmol/L) | 18.8 ** ± 17.2 | 6.5 ± 3.2 | <0.01 | −55.7 ± 26.7% |
| Serum calcium ion (4.3–5.3 mg/dL) | 5.72 ** ± 0.18 | 4.76 ± 0.46 | <0.01 | −16.6 ± 9.3% |
| Total serum calcium (8.5–10.1 mg/dL) | 10.5 ** ± 0.7 | 9.4 ± 0.7 | <0.01 | −10.7 ± 7.7% |
| Serum phosphate (2.5–4.9 mg/dL) | 2.7 ± 0.4 | 3.3 ± 0.5 | <0.01 | +28.1 ± 28.5% |
| 25-hydroxy-vitamin D (30–100 ng/mL) | 33.3 ± 8.4 | 37.0 ± 11.8 | Not significant | +17.9 ± 48.1% |
| Bone alkaline phosphatase (Men: 7–20 µg/L; pre-menopausal women: 4–14.3 µg/L; post-menopausal women: 6–22.5 µg/L) |
24.1 ** ± 8.3 | 12.3 ± 2.9 | <0.01 | −43.5 ± 27.0% |
| Urinary calcium (42–353 mg/24 h) | 322.7 ± 129.6 | 213.1 ± 141.7 | <0.05 | −28.9 ± 40.7% |
| Urinary phosphate (400–1300 mg/24 h) | 678.3 ± 224.3 | 397.0 ± 108.1 | Not significant | +38.9 ± 15.3% |
| Urinary deoxypyridinoline (3.0–5.4 mnol/mmol creatinine) | 9.4 ** ± 2.2 | 6.9 ** ± 1.0 | <0.05 | −22.4 ± 28.2% |
1 = normal values are indicated within brackets. ** indicate a parameter value higher than the normal range. The statistical significance (p value) is indicated in bold.