Figure 1.

Observed changes in metabolite concentrations upon acquired resistance. Oxaliplatin (OxR) and BOLD-100/KP1339 (RuR) resistance models are compared to their sensitive counterparts. Relative differences in the measured metabolite concentrations of resistant and sensitive cells are shown. A positive relative difference (red) indicates a higher metabolite concentration in the resistant as compared to the parental sensitive model, whereas a negative relative difference (blue) indicates a lower metabolite concentration in the resistant than in the sensitive counterpart. Relative differences were calculated from using the mean values of six replicates. Only those metabolites for which we observed an absolute relative change greater than 15% between sensitive and resistant, in at least one of the two conditions, are shown. The following abbreviations were used: ADP—adenosine diphosphate, AMP—adenosine monophosphate, CMP—cytidine monophosphate, CTP—cytidine triphosphate, GMP—guanosine monophosphate, IMP—inosine monophosphate, NAD—nicotinamide adenine dinucleotide, UDP—uridine diphosphate, UMP—uridine monophosphate, UTP—uridine triphosphate, CoA—coenzyme A, dATP—deoxyadenosine triphosphate, dCMP—deoxycytidine monophosphate.