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. 2021 Aug 17;13(16):4130. doi: 10.3390/cancers13164130

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Comparison of fluxes through key energy metabolism reactions for ruthenium- and oxaliplatin-based resistant cells after growth rate normalization. Growth normalized flux values through (a) the oxygen uptake reaction—HMR_9048, (b) the ATP synthase reaction—HMR_6916, (c) the lactate secretion reaction—HMR_9135, and (d) the fatty acid influx—sum of m01362s_FAx, m02387s_FAx, m02389s_FAx, m02646s_FAx, m02674s_FAx, m02938s_FAx, across the four model instances (sensitive, Sen—blue bars; sensitive in a DMSO-containing medium, Sen-DMSO—gray bars; oxaliplatin-resistant, OxR—red bards; BOLD-100/KP1339, RuR—yellow bars) are shown. Fatty acid influx is the combined influx of stearate, palmitate, oleate, linolenate, linoleate, arachidonate.