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. 2021 Aug 17;13(16):4130. doi: 10.3390/cancers13164130

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Simulating minimum fatty acid uptake requirement in response to various oxygen uptake constraints. Oxygen influx constraints were applied to each of the model instances (a) sensitive, (b) oxaliplatin-resistant, (c) sensitive in DMSO-containing medium, and (d) BOLD-100/KP1339-resistant. Using a parsimonious thermodynamic flux variability analysis (pTFVA; see Methods and Materials for details) the minimum possible fatty acid uptake was calculated for each oxygen constraint as shown. Fatty acid influx is the combined influx (black line) of stearate (orange), palmitate (cyan), oleate (dark purple), linolenate (yellow), linoleate (green), arachidonate (light purple).