Figure 5.

Laboratory diagnostic strategy. The scheme summarizes the appropriate diagnostic testing to prescribe for each form of porphyria. The striped boxes represent the tests that are not mandatory to prescribe before starting a therapy. In particular, fecal porphyrins and DNA analysis could be avoided during acute attack if other tests are positive and they can be postponed to the phases of latency. Of note, in the sporadic form of PCT, no mutation is expected to be found in UROD gene.