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. 2021 Aug 20;13(16):4198. doi: 10.3390/cancers13164198

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Serum neurofilament light chain and plasma brain-derived neurotrophic factor levels are altered after chemotherapy treatment. Neurofilament light chain (NfL) and brain derived-neurotrophic factor (BDNF) levels were measured in serum and plasma, respectively, of 19 C+ (breast cancer patients treated with chemotherapy), 18 C− (chemotherapy-naïve breast cancer patients) and 33 HC (healthy women) and showed to be altered in C+ compared to both control groups for NfL and only compared to HC for BDNF. Individual values with group medians are presented. The dotted line indicates diagnostic cutoff level for neurodegenerative disease with NfL immunoassay serum measurement. Group differences were assessed with ANOVA analysis with group as factor and age as covariate, with post-hoc least significance difference tests to assess which groups differ. *** p < 0.001, * p < 0.01.