↓ΔΨm |
mitochondrial membrane potential depolarization |
•NO |
nitric oxide |
•OH |
hydroxyl radical |
4-HNE |
4-hydroxynonenal |
α-KΓ |
Alpha-ketoglutarate |
α-KΓΔH |
alpha-ketoglutarate dehydrogenase |
ACAD10 |
acyl-CoA dehydrogenase family member 10 |
ACS |
acyl-CoA synthetase |
Acn |
aconitase |
AGE |
advanced glycation end products |
AKR1A1 |
aldo-keto reductase family 1 member A1 |
AKI |
acute kidney injury |
AMPK |
adenosine monophosphate (AMP)-activated protein kinase |
Ang II |
angiotensin II |
Arg |
arginine |
ATP |
adenosine triphosphate |
ATR-1 |
angiotensin type 1 receptor |
Bcl-2 |
B cell lymphoma 2 |
BUN |
blood urea nitrogen |
CI |
complex I |
CII |
complex II |
CIII |
complex III |
CIV |
complex IV |
CV |
complex V |
C5aR1 |
C5 substrate of the complement system receptor 1 |
CAT |
catalase |
CBS |
cystathionine β-synthase |
CD36 |
cluster of differentiation-36 |
CKD |
chronic kidney diseases |
CoA |
coenzyme A |
Cox I |
cytochrome c oxidase subunit 1 |
CPT I |
carnitine O-palmitoyl transferase I |
CPT II |
carnitine O-palmitoyl transferase II |
CPT IA |
CPT I isoform A |
CPT IB |
CPT I isoform B |
CSE |
cystathionine γ-lyase |
Cu/Zn-SOD |
copper/zinc-SOD |
Cys |
cysteine |
CARSs |
cysteinyl-transfer RNA (tRNA) synthetases |
Cyt c |
cytochrome c |
DKD |
diabetic kidney disease |
DN |
diabetic nephropathy |
DNA |
deoxyribonucleic acid |
Drp1 |
dynamin-related protein 1 |
DT |
distal tubules |
EGFR |
epidermal growth factor receptor |
EMT |
epithelial–mesenchymal transition |
eNOS |
endothelial nitric oxide synthase |
ERK2 |
extracellular regulated kinase 2 |
ERR |
estrogen and estrogen-related receptors |
ETS |
electron transport system |
FA |
fatty acids |
FABP |
fatty-acid-binding protein |
FADH2
|
flavin adenine dinucleotide |
Fe2+
|
ferrous iron |
Fe3+
|
ferric iron |
Fe-S |
iron-sulfur |
Fis1 |
fission protein 1 |
FoxO |
forkhead box O |
GC4419 |
avasopasem manganese |
GFRs |
growth factor receptors |
GPx |
glutathione peroxidase |
Grx |
glutaredoxin |
GSH |
glutathione |
GTPases |
guanosine triphosphatases |
GST |
glutathione S-transferase |
h |
hours |
HK2 |
human proximal tubular cells |
HS•
|
hydrosulfide radical. |
H2O2
|
hydrogen peroxide |
H2S |
gydrogen sulfide |
His |
histidine |
I/R |
ischemia/reperfusion |
Idh2 |
isocitrate dehydrogenase isoform 2 |
IKKγ |
regulatory subunit of inhibitor IKK complex |
IMM |
inner mitochondrial membrane |
IMS |
intermembrane space |
K2Cr2O7
|
potassium dichromate |
L-NAME |
N(G)-nitro-L-arginine-methyl ester |
LC3-II |
microtubule-associated protein 1A/1B-light chain 3 phosphatidylethanolamine conjugate |
LDs |
lipid droplets |
LOO•
|
lipid peroxyl radical |
LPS |
lipopolysaccharides |
Lys |
lysine |
MA |
maleic acid |
MAPK |
mitogen-activated protein kinases |
MCAD |
medium-chain acetyl dehydrogenase |
MDA |
malondialdehyde |
Met |
methionine |
MetO (R–SOCH3) |
methionine sulfoxide |
MetO2 (RSO2CH3) |
methionine sulfone |
Mff |
mitochondrial fission factor |
Mfn1 |
mitofusin 1 |
Mfn2 |
mitofusin 2 |
Mief1 |
mitochondrial elongation factor 1 |
Mief2 |
mitochondrial elongation factor 2 |
mitoTEMPO |
2-(2,2,6,6-tetramethylpiperidin-1-oxyl-4-ylamino)-2-oxoethyl) triphenylphosphonium chloride |
mitoQ |
mitochondrial-targeting antioxidants coenzyme Q |
Mn-SOD |
manganese superoxide dismutase |
mRNA |
messenger RNA |
Msr |
methionine sulfoxide reductase |
MsrA |
Msr isoform A |
MPTP |
mitochondrial permeability transition pore |
mt-KATP
|
mitochondrial ATP-sensitive potassium K channel |
mtDNA |
mitochondrial DNA |
mtROS |
mitochondrial ROS |
Na+/K+ ATPase |
sodium–potassium ATP pump |
NAC |
N-acetylcysteine |
NAD |
nicotinamide adenine dinucleotide |
NADPH |
nicotinamide adenine dinucleotide phosphate |
NaHS |
sodium hydrosulfide |
NF-κB |
nuclear factor kappa-light-chain-enhancer of activated B cells |
NOS |
nitric oxide synthase |
NOXs |
NADPH oxidases |
NRF-1 |
nuclear respiratory factor 1 |
NRF-2 |
nuclear respiratory factor 2 |
Nrf2 |
nuclear factor erythroid 2–related factor 2 |
O2
|
oxygen |
O2•−
|
superoxide anion radical |
OA |
oxalacetate |
OCR |
oxygen consumption rate |
OMM |
outer mitochondrial membrane |
ONOO−
|
peroxynitrite |
Opa1 |
optical atrophy 1 |
OS |
oxidative stress |
Ox-PTMs |
oxidative post-translational modifications |
OXPHOS |
oxidative phosphorylation |
p62 |
sequestosome |
PDIA1 |
protein disulfide isomerase A1 |
PGC-1α |
peroxisome proliferator-activated receptor (PPAR) γ coactivator-1 alpha |
Pink1 |
phosphatase and tensin homolog (PTEN)-induced putative kinase 1 |
PKC |
protein kinase C |
PKC-ε |
PKC-epsilon |
PKC-δ |
PKC-delta |
PKM2 |
pyruvate kinase isoform M2 |
PMF |
proton motive force |
PPARs |
peroxisome proliferator-activated receptor |
Pro |
proline |
Prx |
peroxiredoxin |
PT |
proximal tubules |
PTKs |
protein tyrosine kinases |
PTM |
post-translational modifications |
PTPs |
protein tyrosine phosphatases |
R–S•
|
thyil radical |
R–SNO |
S-nitrosothiol |
R–SOH |
sulfenic acid |
R–SO2H |
sulfinic acid |
R–SO3H |
sulfonic acid |
R–S(O)–S–R |
thiosulfinate |
R–SN–R’ |
sulfenamide |
R–S–S–H |
persulfonation |
Rac1 |
Ras-related C3 botulinum toxin substrate 1 |
RAGE |
AGE receptor |
ROS |
reactive oxygen species |
RPTCs |
renal proximal tubular cells |
RTC |
renal tubular cells |
S−
|
thiolate anion |
S–S |
disulfide bonds |
SF |
sulforaphane |
SH |
thiol |
siRNA |
small interfering RNA |
SIRT3 |
nicotinamide adenine dinucleotide (NAD)-dependent deacetylase sirtuin-3 |
SN2 |
bimolecular nucleophilic substitution |
SSG |
glutathionylation |
TCA |
tricarboxylic acid |
TECs |
tubular epithelial cells |
TFAM |
transcription factor A |
TGFβ1 |
transforming growth factor-beta 1 |
Thr |
threonine |
Trx |
thioredoxin |
Tyr |
tyrosine |
UCPs |
uncoupling proteins |
UCP1 |
uncoupling protein 1 |
UCP2 |
uncoupling protein 2 |
UCPs |
uncoupling proteins |
UUO |
unilateral ureteral obstruction |
VLCAD |
very long-chain acyl-CoA dehydrogenase |
WT |
wild type |