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The role of UPRmt and mitokines in cancer progression. When mitochondria are under stress, OXPHOS perturbations, ROS production, and the level of unfolded proteins increase. Increased expression of proteases (ClpP & LONP1) and chaperone proteins (HSP60) during UPRmt promotes mitokine (FGF21 & GDF15) expression, which affects tumor development and progression. LONP1, Lon protease 1.
