FIG. 1.

Identification of dosage suppressors of the Ts prp38-1 mutation. Yeast cultures were streaked on nonselective medium and incubated at 23 and 37°C. The colony sizes of the untransformed prp38-1 mutant and wild-type (PRP38) yeast strains are compared with those of the prp38-1 mutant transformed with the indicated multi-copy plasmids. The plasmids encoded a functional PRP38 gene (YEp13-2), a weak suppressor of prp38-1 (YEp13-5), or an efficient suppressor of prp38-1 (YEp13-7 and YEplac112-7A).