Table 2.
Downregulated miRNAs in pulp inflammation.
| miRNA | Target Gene | MiRNA Function | Ref |
|---|---|---|---|
| miR-Let-7c | IL-13, IκB-α 1, IKK-β1, IGF-1R, DMP-1 1, HMGA2/PI3K/Akt 1 | Osteo/odontogenic differentiation in DPMSCs Response to mechanical stimuli Pro-inflammatory Anti-inflammatory 1 Promoting osteogenic differentiation 1 |
[51,94,128,129,130] |
| miR-25b | TNF-α, Fyn | Development and maintenance of orofacial inflammatory pain | [94,132,135,136] |
| Anti-inflammatory and improve odontogenic differentiation | |||
| miR-30b | IL-6R | Attenuate the phagocytosis 2 Anti-inflammatory activity 2 |
[142] |
| miR-152 | IL-6, TLR-4, MAPK8, SIRT7 | Negative regulator of the innate immune response Protect against neuroinflammation 3 Anti-inflammatory 3 Response to cold, heat, and mechanical stimuli |
[51,52,146,147,148] |
| miR-181 family |
IL-6, IL-2, TGFB1, STAT1 CCL8, MMP9, IL-8 | Pro-inflammatory Response to thermal and mechanical stimuli |
[51,155,156,157,158,159,160,161] |
| miR-204 | IL-6R, MM9 | Anti-inflammatory activity | [163] |
| miR-221 | Stem cell factor receptor c-Kit, p27 | Inhibits endothelial cell migration, proliferation, and angiogenesis Antiapoptotic Anti-inflammatory 4 |
[166,167,168,169] |
| miR-410 | HMGB1 | Anti-inflammatory 5 | [176,177] |
1 MiR-Let-7c overexpression; 2 MiR-30b overexpression; 3 MiR-125 overexpression; 4 MiR-221 overexpression; 5 MiR-410 overexpression.