Table 1.

Key metabolic pathways associated with lung squamous cell cancer metastasis.

No.	Metabolism	Interaction Metabolite	Total 1	Hits 2	p 3	Impact 4
1	Alanine, aspartate and glutamate metabolism	Alanine, asparagine, aspartic acid, fumaric acid, glutamic acid, succicnic acid	24	6	7.58 × 10−6	0.55
2	Glycine, serine, and threonine metabolism	Aspartic acid, cysteine, glycine, glyceric acid, serine, threonine, tryptophan	48	7	5.42 × 10−5	0.42
3	Arginine and proline metabolism	Aspartic acid, creatinine, fumaric acid, glutamic acid, hydroxyproline, proline, putrescine,	77	7	1.09 × 10−3	0.27
4	β-Alanine metabolism	β-Alanine, aspartic acid, uracil	28	3	2.13 × 10−2	0.26
5	Aminoacyl-tRNA biosynthesis	Alanine, asparagine, aspartic acid, cysteine, glutamic acid, glycine, isoleucine, leucine, lysine, methionine, serine phenylalanine, proline, threonine, tryptophan, tyrosine, valine	75	17	3.55 × 10−14	0.23
6	Glycerolipid metabolism	Glyceric acid, glycerol, glycerol-3-phosphate	32	3	3.04 × 10−2	0.22
7	Cysteine and methionine metabolism	Alanine, asparagine, cysteine, methionine, serine	56	5	6.42 × 10−3	0.18
8	Phenylalanine metabolism	Fumaric acid, phenylalanine, succinic acid, tyrosine	45	4	1.50 × 10−2	0.12

¹ Total is the total number of compounds in the metabolism. ² Hits is the matched number of compounds from the uploaded data set. ³ p is the p value calculated from the pathway analysis. ⁴ Impact is the cumulative percentage from matched metabolites in each total pathway. The threshold of 0.1 was set to filter less important pathways.