Table 1.
Roles of TSGs on chromosome 3 during nasopharyngeal carcinogenesis.
| Gene | Location | Roles | References |
|---|---|---|---|
| ADAMTS9 | 3p14.1 | Angiogenesis | [6] |
| PTPRG | 3p14.2 | Chromosomal translocations and deletions, cell cycle | [18] |
| BLU | 3p21.3 | Cell progress, stress-response | [7,16,17,19,20] |
| GNAT1 | 3p21.3 | Remains to be revealed | [21] |
| LARS2 | 3p21.3 | Protein synthesis | [22] |
| LTF | 3p21.3 | Immunomodulatory, homeostasis, anti-tumor activity, cell growth, cell cycle regulatory | [23,24,25] |
| MLH1 | 3p21.3 | Mismatch repair | [26,27] |
| RASSF1A | 3p21.3 | Cell proliferation, cell cycle regulation, apoptosis, micro-tubular stabilization | [5,13,26,27,28,29,30,31,32,33,34,35,36,37,38] |
| ITGA9 | 3p21.3 | Cell––cell and cell–matrix adhesion | [15] |
| DLEC1 | 3p22.2 | Cell communication, signaling transduction, cell proliferation | [7,38,39,40] |
| RAR-β | 3p24.2 | Hormone receptor, transcriptional regulator, retinoic acid signaling, cell growth and differentiation | [28,30,36] |
| VLH1 | 3p25.3 | Ubiquitination | [27] |
| TIG1 | 3q25.3 | Cell-to-cell contact | [39,41] |