Table 3.

MicroRNAs that mediate antitumor response to CDK4/6 inhibitors.

miRNA	Tumor Type	CDK4/6 Inhibitor	miRNA Expression	miRNA Mediated Mechanism	Biological Sample	Detection Method	References
miR-124a	ALL	Palbociclib	Epigenetic downregulation	Upregulation of CDK6	ALL-derived cell lines, animal models	miRNA assay, qRT-PCR, ChIP-PCR	[48]
miR9	ALL	Palbociclib	Epigenetic downregulation	Upregulation of CDK6	ALL-derived cell lines	MicroRNA assay	[49]
miR200b	Lung cancer	Palbociclib	Downregulation	Upregulation of CCND1 via upregulation of QKI	Lung adenocarcinoma cell lines, animal models	qRT-PCR, microRNA assay	[50]
miR-106b	ER+ BC	Palbociclib	MCM7 mediated downregulation	Upregulation of p21 and PTEN	Breast cancer cells lines, FFPE	GeneChIP miRNA arrays, qRT-PCR, IHC	[53]