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. 2021 Aug 17;9(8):1026. doi: 10.3390/biomedicines9081026

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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A somatic mutation in KCNJ5 157-159delITE in aldosterone-producing adenoma. (A) Sequences of blood and tumor genomic DNA of KCNJ5 in APA. Of note, KCNJ5 157-159delITE mutation is noted in adenoma but not blood nuclear cells. (B) The modeling structure of human KCNJ5 was generated by the Phyre2 web serve. The red color region marked by red arrow in wild-type KCNJ5 indicates the location of isoleucine (Ile, I) 157, threonine (Thr, T) 158 and glutamine (Glu, E)159. The mutation site of 157-159delITE in KCNJ5 is located in the loop region near the selectivity filter of the potassium channel. (C) The evolutionary conservation analysis of amino acids I157, T158 and E159 are conserved in different species.