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. 2021 Aug 17;10(8):2111. doi: 10.3390/cells10082111

Figure 2.

Figure 2

PMN-MDSC induced platelet activation by reducing L-arginine. (a) Correlation between PAC-1 platelet expression (mfi) and PMN-MDSC percentage from SARSCoV-2 infected patients (ICU n = 21, no ICU n = 15) and HD (n = 9). Non-parametric Spearman correlation was applied. (b) Representative histogram plot showing PAC-1 expression on platelets after culture with or without PMN-MDSC or PBMC depleted from MDSCs (PBMC). (c) PAC-1 expression on platelets from HD (n = 6) after culture with PMN-MDSC or PBMC from SARSCoV-2 infected patients (n = 6). Results are shown as median and IQR. Wilcoxon matched-pairs signed rank test was applied. (d) L-arginine reduction (ΔArg) calculated as the difference between L-arginine concentration in the presence of MDSCs or PBMC and platelets alone. Results are shown as median and IQR. A Wilcoxon matched-pairs signed rank test was applied.