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. 2021 Aug 4;13(16):3928. doi: 10.3390/cancers13163928

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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CENP-A nuclear localization pattern is a marker of disease control by CCRT in HNSCC patients. (A) CENP-A IHC images of HNSCC biopsies corresponding to CENP-A pattern-C. Scale bar is 10 µm. A scheme depicting the pattern is shown on the right (B) as in (A), but for CENP-A pattern non-C. (C) Graph showing proportion (in %) of disease control in biopsies from patients displaying CENP-A pattern-C or non-C. (D) Kaplan–Meier survival curve of patients treated by CCRT with CENP-A pattern-C (black) and CENP-A pattern non-C (red).