Table 1.

Summary of the main findings of the effects on Histatin 5 by the metallic complexation.

Metal	Coordination Site in Hst5	Complexation Effects	Reference
Copper	ATCUN	Improves peptide stability Enhances antifungal activity Raises ROS liberation Enhances the fungus nutritional hunger	[92] [93] [95]
Zinc	HEXXH	Improves peptide’s functional domain stability Improves the stability of peptide’s α-helical conformation Destabilizes fungus lipidic bilayer Promotes fungus acid nucleic hydrolysis Little protection on peptide proteolytic degradation	[42] [83] [95]
Nickel	ATCUN	Improves the stability of peptide’s α-helical conformation Facilitates the peptides bond with fungus DNA	[41] [100]
Iron	uncertain	Minimizes drastically antifungal activity Enhances the fungus nutritional hunger Affects the peptides interaction with the fungal cell wall Interferes on iron cellular metabolism, leading fungal mitochondria to death	[83] [92]
Calcium	uncertain	Inhibits antifungal activity Suppresses ATP efflux Interrupts the bond between peptide and fungus cell	[101]
Magnesium	uncertain	Minimizes antifungal activity Decreases ATP efflux	[101]