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. 2021 Jul 27;12(8):1146. doi: 10.3390/genes12081146

Figure 2.

Figure 2

Model of Polθ dependency in HR-deficient cells. (A) DSBs are predominantly repaired in S/G2 cell cycle phases by accurate HR, which is promoted by BRCA1/2, RAD51, and associated proteins. Polθ-dependent MMEJ serves as a backup DSB repair pathway that acts on 3′ ssDNA overhangs and causes large indels. (B) HR-deficient cells rely on Polθ-dependent MMEJ for DSB repair and cell survival. (C) Inactivation or suppression of Polθ causes synthetic lethality in HR-deficient cells as a result of insufficient DNA repair.