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. 2021 Aug 16;11(8):1219. doi: 10.3390/biom11081219

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(A) Immunostaining for HMGB1 of a patient positive for SARS-CoV-2: note the internal positive control of normal epidermal keratinocytes and positivity in the cells constituting the excretory portion of the eccrine sweat glands that were strongly positive for anti-S1 spike protein immunostaining by SARS-CoV-2 (Immunohistochemistry, Original Magnification: 40×). (B) Detail of extracellular release of HMGB1 (Immunohistochemistry, Original Magnification: 200×). (C) Immunostaining for HMGB1 of a patient negative for SARS-CoV-2: note the internal positive control and substantial negativity in the cells of superficial dermis (Immunohistochemistry, Original Magnification: 40×). (D) Detail of negativity for HMGB1 (Immunohistochemitry, Original Magnification: 100×).