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. 2021 Aug 16;11(8):1219. doi: 10.3390/biom11081219

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(A) Immunostaining for HO-1: note the positivity of a few inflammatory cells available mainly subepithelial in the skin of a patient positive for SARS-CoV-2 (Immunohistochemistry, Original Magnification: 40×). The light brown color is linked to “background noise” of the immunohistochemical reaction. (B) Photomicroghaph of skin biopsy of a patient negative for SARS-CoV-2 with higher expression of HO-1 in the epidermis and of inflammatory cells in subepithelial disposition (Immunohistochemistry, Original Magnification: 100×).