Table 1.
(A) General characteristics of all the study patients. (B) General characteristics in the two clusters of bronchiectasis patients, excluding those with COPD.
| (A) | ||
| Below-Threshold Cluster | Above-Threshold Cluster | |
| (N = 270) | (N = 636) | |
| Anthropometric variables, (SD) | ||
| Age, years | 68.8 (13.8) | 67 (15.1) |
| Body weight, kg | 65.3 (15.1) | 68.7 (14.4) ** |
| BMI, kg/m2 | 25.2 (5.2) | 26.4 (5) ** |
| Disease severity, (SD) | ||
| FACED score | 2.21 (1.82) | 2.07 (1.64) |
| EFACED score | 3.11 (2.40) | 2.65 (2.09) ** |
| BSI | 8.60 (4.96) | 7.29 (4.51) *** |
| Exacerbations | 1.82 (1.97) | 1.39 (1.45) ** |
| Hospitalizations | 0.84 (1.30) | 0.56 (1.38) ** |
| Charlson Index | 2.0 (1.71) | 1.83 (1.53), p = 0.1 |
| Chronic colonization by PA, N (%) | 62 (23) | 166 (26) |
| Smoking history | ||
| Never smokers, N (%) | 152 (56) | 375 (59) |
| Current smokers, N (%) | 28 (11) | 58 (9) |
| Ex-smokers, N (%) | 90 (33) | 203 (32) |
| Packs-year, (SD) | 14.5 (23.9) | 11.9 (21.1) |
| Lung function, (SD) | ||
| FEV1, % predicted | 71 (27) | 75 (24) * |
| FVC, % predicted | 83 (24) | 86 (21), p = 0.065 |
| FEV1/FVC, % | 67 (13) | 69 (13) ** |
| DLCO, % predicted | 76 (23) | 85 (24) ** |
| KCO, % predicted | 77 (34) | 77 (39) |
| RV, % predicted | 137 (40) | 138 (53) |
| TLC, % predicted | 99 (20) | 103 (20) |
| RV/TLC, % | 52 (10) | 49 (12), p = 0.061 |
| (B) | ||
| Below-Threshold Cluster | Above-Threshold Cluster | |
| (N = 236) | (N = 567) | |
| Anthropometric variables, (SD) | ||
| Age, years | 67.8 (14.0) | 66.0 (15.3) |
| Body weight, kg | 64.4 (14.6) | 68.1 (14.2) ** |
| BMI, kg/m2 | 25.0 (5.2) | 26.3 (5.0) ** |
| Disease severity, (SD) | ||
| FACED score | 2.03 (1.76) | 1.92 (1.52) |
| EFACED score | 2.85 (2.31) | 2.45 (1.93) * |
| BSI | 8.08 (4.79) | 6.86 (4.22) ** |
| Exacerbations | 1.75 (1.98) | 1.35 (1.44) ** |
| Hospitalizations | 0.76 (1.3) | 0.51 (1.36) * |
| Charlson Index | 1.92 (1.69) | 1.75 (1.47) |
| Chronic colonization by PA, N (%) | 30 (25) | 171 (25) |
| Smoking history | ||
| Never smokers, N (%) | 151 (64) | 368 (65) |
| Current smokers, N (%) | 20 (8) | 45 (8) |
| Ex-smokers, N (%) | 65 (28) | 154 (27) |
| Packs-year, (SD) | 10.1 (19.4) | 7.8 (15.6) |
| Lung function, (SD) | ||
| FEV1, % predicted | 74 (27) | 78 (23), p = 0.07 |
| FVC, % predicted | 85 (24) | 87 (21) |
| FEV1/FVC, % | 68 (13) | 71 (11) ** |
| DLCO, % predicted | 79 (22) | 87 (23) * |
| KCO, % predicted | 78 (33) | 78 (39) |
| RV, % predicted | 134 (38) | 134 (49) |
| TLC, % predicted | 98 (20) | 101 (18) |
| RV/TLC, % | 52 (10) | 49 (12), p = 0.084 |
Continuous variables are presented as the mean (standard deviation), while categorical variables are presented as the number of patients in each group, along with the percentage for the study group. Definitions of the abbreviations: N, number; kg, kilograms; m, meters; BMI, body mass index; BSI, bronchiectasis severity index; PA, Pseudomonas aeruginosa; FEV1, forced expiratory volume in the first second; FVC, forced vital capacity; RV, residual volume; TLC, total lung capacity; DLco, carbon monoxide transfer; KCO, Krogh transfer factor. Statistical analyses and significance: *, p < 0.05; **, p < 0.01; ***, p < 0.001 between the patient groups.