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. 2021 Aug 11;13(16):4041. doi: 10.3390/cancers13164041

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The interaction of lncRNAs with different biomolecules tunes their biological activity. LncRNAs can interact with proteins, DNA, or RNA, acting as (A) scaffolds of proteins, (B) decoys, preventing protein–oligonucleotide complex formation, (C) guides for (i) proteins or (ii) oligonucleotides, (D) enhancers, promoting transcription, (E) miRNAs sponges, or (F) mRNA inhibitors, blocking mRNA function due to (i) mRNA degradation, (ii) blocking translation, or (iii) competing for binding sites. Created with BioRender.com, accessed on 26 October 2020.