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. 2021 Aug 6;10(8):2014. doi: 10.3390/cells10082014

Figure 3.

Figure 3

Focal IF/TA and diffuse fibrosis are indicative of injury to distinct renal compartments in ANCA GN. (A) Representative photomicrograph of Masson’s trichrome-stained kidney section in ANCA GN (scale bar: 200 μm). (B) Association between total kidney fibrosis, clinical and laboratory findings in ANCA GN are shown by heatmap reflecting mean values of Spearman’s ρ, asterisks indicate p < 0.05. (C) Association between total kidney fibrosis, glomerular and inflammatory findings in ANCA GN are shown by heatmap reflecting mean values of Spearman’s ρ, asterisks indicate p < 0.05. (D) Representative photomicrograph of Masson’s trichrome-stained kidney section in ANCA GN with focal IF/TA (upper panel) and diffuse fibrosis (lower panel) are shown (scale bars: 40 μm). (E) Association between focal IF/TA and diffuse fibrosis with glomerular and inflammatory findings are illustrated by heatmap reflecting mean values of Spearman’s ρ, asterisks indicate p < 0.05. (F) Association between focal IF/TA and diffuse fibrosis with clinical and laboratory findings in ANCA GN are shown by heatmap reflecting mean values of Spearman’s ρ, asterisks indicate p < 0.05. Abbreviations: ANCA GN—antineutrophil cytoplasmic antibody glomerulonephritis; BVAS—Birmingham Vasculitis Activity Score; CRP—c-reactive protein; GFR—glomerular filtration rate; IF/TA—interstitial fibrosis/tubular atrophy; IQR—interquartile range; MPO—myeloperoxidase; uACR—urine albumin/creatinine ration; uPCR—urine protein/creatinine ratio.