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Long-term hepatic expression of IR isoforms alters mRNA levels of genes involved in vascular dysfunction: Nos3 (A), Nos2 (B), Et1 (C) and Icam1 (D) mRNA levels by qRT-PCR on aorta artery from control (n = 2–6), iLIRKO (n = 3–11), iLIRKO IRA (n = 3), iLIRKO IRB (n = 3). Results are expressed as mean ± SEM. The statistical significance was represented as * (p < 0.05) vs. control mice; $ (p < 0.05) vs. iLIRKO mice; ## (p < 0.01) vs. iLIRKO IRB mice.
