Table 2.
circRNAs that are potentially relevant for cSCC and BCC development (only species confirmed in >1 study or functionally characterized in cell lines).
| Circular RNA | Dysregulation in KC | Interacting miRNAs | Cellular Effects | Ref. |
|---|---|---|---|---|
| hsa_circ_0070933 | Upregulated in cSCC | Not analyzed experimentally | Not analyzed experimentally | [67,71] |
| hsa_circ_0070934 | Upregulated in cSCC | miR-1238, miR-1247-5p miR-1236-3p |
Increased cell proliferation, migration, and invasion, inhibits apoptosis |
[67,68,71] |
| hsa_circ_0003528 (circSEC24A) |
Upregulated in cSCC | miR-1193 | Increased cell proliferation, migration, and invasion, inhibits apoptosis |
[73] |
| hsa_circ_001937 | Upregulated in cSCC | miR-597-3p | Increased cell proliferation | [69] |
| hsa_circ_0001821 (circPVT1) |
Upregulated in cSCC | Not analyzed experimentally | Increased migration and invasion | [70] |
| hsa_circ_001360 | Downregulated in cSCC | Not analyzed experimentally | Reduced cell proliferation, migration, and invasion | [72] |
| hsa_circ_0067772 | Upregulated in cSCC | miR-1238-3p | Increased cell proliferation, migration and invasion |
[74] |
| hsa_circ_0008234 | Upregulated in cSCC | miR-127-5p | Increased cell proliferation | [75] |
| Circ-CYP24A1 | Upregulated in cSCC | Not analyzed | Increased cell proliferation, migration, and invasion, reduced apoptosis | [76] |
| hsa_circ_0005795 | Upregulated in BCC | miR-1231 | Increased cell proliferation, inhibits apoptosis |
[78] |