Table 2.
Examples of HIFU clinical trials.
| Clinicaltrails.Gov Identifier | Official Title | Purpose of the Study | (Estimated) Primary Completion Date |
|---|---|---|---|
| NCT01117246 | “Pilot Study for the Treatment of Bone Metastases by High Intensity Focused Ultrasound Guided by MRI to Perform Pain Palliation” | Confirm the safety and effectiveness of MR-guided HIFU for pain palliation of skeletal metastases | July 2011 |
| NCT01765907 | “Antalgic Treatment of Painful Bone Metastases by US-guided High Intensity Focused Ultrasound (HIFU)” | Assess safety, including adverse and serious adverse events, local and systemic tolerance of HIFU in patients with bone metastasis | March 2014 |
| NCT01964677 | “Magnetic Resonance-Guided High Intensity Focused Ultrasound for Palliation of Painful Skeletal Metastases—a Multicenter Study” | Evaluate the effectiveness of Philips Sonalleve MR-HIFU device for the palliation of pain in patients with bone metastases | 14 November 2016 |
| NCT02618369 | “Magnetic Resonance-Guided High Intensity Focused Ultrasound for Pain Management of Osteoid Osteoma and Benign Bone Tumors in Children and Young Adults” | Determine if MR-guided HIFU is safe and effective for alleviating pain associated with osteoid osteoma and other benign bone tumors in pediatric patients and adults (up 40 years old) | April 2018 |
| NCT02349971 | “Safety and Feasibility of MR-Guided High Intensity Focused Ultrasound (MR-HIFU) Ablation of Osteoid Osteoma in Children” | Examine the feasibility and efficacy of using MR-HIFU to ablate osteoid osteoma in children and young adults | 3 October 2020 |
| NCT03106675 | “MR Imaging- Guided High Intensity Focused Ultrasound (HIFU) Therapy of Bone Metastases” | Evaluate the effectiveness of MR-guided HIFU in treating metastatic bone tumors | 31 December 2021 |
| NCT02076906 | “Safety and Feasibility Study of Using MR-guided High Intensity Focused Ultrasound (HIFU) for the Ablation of Relapsed or Refractory Pediatric Solid Tumors” | Determine if MR-guided HIFU is safe and feasible for children, adolescents, and young adults with refractory or relapsed solid tumors | 30 January 2022 |
| NCT04658771 | “Pivotal / Phase II Clinical Trial of Magnetic Resonance-Guided Focused Ultrasound (MR-HIFU) Treatment of Painful Osteoid Osteoma in Children and Young Adults” | Determine treatment safety and efficacy of MR-HIFU ablation of painful osteoid osteoma in children and young adults | 30 January 2023 |
| NCT04307914 | “Focused Ultrasound and RadioTHERapy for Noninvasive Palliative Pain Treatment in Patients with Bone Metastases” | Evaluate the effectiveness and cost effectiveness of MR-HIFU (alone or in combination with EBRT) compared to EBRT alone | 1 January 2024 |