Figure 1.

Heatmap representation of the cluster of whole-body animal models for CTD carrying different deletions/mutations of the SLC6A8 gene. Species (M: mouse; R: rat) expression patterns of a mutated allele (C: constitutive; I: inducible) and model generation strategy (KO: knock-out; KI: knock-in) were also cited. The phenotypic traits for each model are indicated (ORT: object-recognition task; MWM: Morris water maze; YM: Y maze; FC: fear conditioning; RM: radial maze; SP: social preference; SG: self-grooming; ROT: rotarod; OF: open field; EZM: elevated zero maze; TST: tail suspension test; LH: learned helplessness; LA: locomotor activity; AS: acoustic startle; SW: swimming behavior; GS: grip strength; PT: pole test; HW: hang wiring; BW: beam walk). Red squares mean significantly higher or lower performance with respect to WT animals. Blue squares refer to phenotypes with no differences between genotypes. Yellow square indicated mixed evidence. Grey squares are for not investigated tasks.