Figure 1.
Dysregulated NF-κB signaling in T-DLBCL. Genomic alterations in the BCR and TLR signaling result in constitutive activation of NF-κB signaling. Aberrations typical for T-DLBCL are marked with red stars. BTK, Bruton’s tyrosine kinase; IRAK, interleukin-1 receptor-associated kinases; JAK, Janus kinase; MALT1, mucosa-associated lymphoid tissue; MTOR, mammalian target of rapamycin; PI3K, phosphoinositide 3-kinase; PKCβ, protein kinase C beta; STAT, signal transducer and activator of transcription; SYK: spleen-associated tyrosine kinase; TLR, toll-like receptor. Adapted from King et al., 2021 [88].
