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. 2021 Aug 12;13(16):4057. doi: 10.3390/cancers13164057

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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CD44 promoted migration and invasion abilities of lung cancer cells through ERK–ZEB1 signaling. (A) Western blot showing the expression pattern of p-ERK, ERK, Claudin-1, and ZEB1 in CD44-knockdowned A549 and H1299 cells. (B) Western blot showing the expression pattern of p-ERK, ERK, Claudin-1, and ZEB1 in CD44-overexpressing H441 and CL1-0 cells. (C) Effect of ERK inhibitor (PD98059, 25 uM) treatment for 48 h on migration and invasion abilities of CD44-overexpressing H441 and CL1-0 cells. (D) Western blot showing the expression pattern of p-ERK, ERK, Claudin-1, and ZEB1 in CD44-overexpressing H441 and CL1-0 cells after ERK inhibitor PD98059 (25 uM for 48 h) treatment. * p < 0.05, ** p < 0.01.