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Schematic diagram of human UPF1. Specific regions and domains within UPF1 are indicated. The helicase domain is composed of two RecA-like domains. Numbers and dots indicate the position of amino acid residues and experimentally validated phosphorylation sites, respectively. CH, cysteine- and histidine-rich domain; HD, helicase domain; and SQ, serine- and glutamine-rich domain.
