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. 2021 Jul 29;11(8):1005. doi: 10.3390/brainsci11081005

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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EWcp is part of the central circuit that controls sympathetic-innervated targets. There are several possible pathways for the early infection of EWcp after PRV injection in organs/tissues: (1) via indirect multisynaptic pathway through brainstem presympathetic neurons; (2) via direct projections to interneurons in the spinal cord; or (3) via sparse direct projections to SPNs in the IML. Infection of EWcp neurons at later survival times might include multisynaptic pathways. Abbreviations: IN, interneuron; SPN, sympathetic preganglionic neuron. Coronal section templates were obtained from the rat brain atlas from Paxinos and Watson, 3rd ed. [115].