Figure 6.

Connections of EWcp with the circuit responsible for stress-induced hyperthermia. Activation of presympathetic neurons in RPa, driven by glutamatergic inputs from DMH, is required for BAT sympathetic nerve activation and subsequent stress-induced hyperthermia. EWcp receives inputs from DMH and projects to RPa, which expresses CRF-R1, receives Ucn-1 innervation (presumably from EWcp), and becomes activated by central administration of Ucn-1. Moreover, stressors that induce hyperthermia activate Orx neurons in LH-PeF and Ucn-1 neurons in EWcp. Orx neurons directly project to RPa and EWcp, which contain Orx-R1. EWcp provides output to brainstem presympathetic regions involved in the sympathetic control of BAT and also the tail artery, which is a key element for cutaneous vasoconstriction in rodents. For terms, see the list of abbreviations.