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. 2021 Jul 29;11(8):1005. doi: 10.3390/brainsci11081005

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Connections of EWcp with melanocortin pathways from Arc. EWcp receives α-MSH (anorexigenic) and AgRP (orexigenic) projections from Arc and expresses MC4R. Fasting decreases α-MSH signal and increases AgRP signal in EWcp, whereas MC4R blockade in EWcp mimics the effects of fasting. α-MSH injection into EWcp decreased food intake and increased oxygen consumption. These data support the involvement of MC4R signaling in EWcp in the control of food intake and metabolism. For terms, see the list of abbreviations.