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CD3+ lymphocytes (red) along a penetrating blood vessel in Cup/EAE mice. The brain surface is shown on the left. Area 1 represents the most superficial part of the neocortex whereas Area 5 is adjacent to the white matter tract corpus callosum. The perivascular Virchow–Robin space is demarcated by the two basal laminae (laminin+; green). Note the increasing cell densities towards the depth of the brain. Scale bars: upper left: 100 µm, right: 10 µm.
