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. 2021 Aug 13;12(8):1241. doi: 10.3390/genes12081241

Figure 4.

Figure 4

Schematic diagram of the ABCA4 protein actively transporting NrPE from the luminal side of the photoreceptor disc membrane to the cytoplasmic side. The ADP is initially bound to the NBD and the ABCA4 binds the NrPE on the luminal side of the photoreceptor disc membrane; this is followed by binding of ATP to the NBDs, leading to a conformational change that creates a low affinity binding site on the cytoplasmic side, resulting in dissociation of the NrPE from the ABCA4 protein and followed by hydrolysis of the ATP, returning the ABCA4 to its primary conformation. Adapted from Molday et al. [37]. Created with BioRender.com (accessed on 1 June 2021). Abbreviations: NBD: nuclear binding domain; NrPE: N-retinylidene phosphatidylethanolamine.