Table 1.
Major lncRNAs in pancreatic cancer.
| lncRNA | Role | Functions | Related Signaling | Ref. |
|---|---|---|---|---|
| HOTAIR | Oncogenic. Up-regulated in cancer. |
Promote proliferation and drug resistance. | EZH2, miR-34a. | [52,53,54,55,56,57] |
| MALAT-1 | Oncogenic. Up-regulated in cancer. |
Promote cell growth, migration, invasion and metastasis. | Sox-2, EZH2, miR-216a, miR-217, miR-200c, Hippo-YAP. | [58,59,60,61,62,63,64,65,66] |
| H19 | Oncogenic. Up-regulated in cancer. |
Promote cell proliferation, tumor growth and metastasis. | let-7, HMGA2, E2F, miR-675, miR194. | [67,68,69,70,71,72] |
| PVT1 | Oncogenic. Up-regulated in cancer. |
Promote cell proliferation, migration, drug resistance. | p21, miR-448, miR-20a-5p, ULK1, miR519, HIF-1, YKT6, RAB7, VAMP3. | [73,74,75,76,77,78,79,80,81] |
| HOTTIP | Oncogenic. Up-regulated in cancer. |
Promote cell growth, invasiveness and drug resistance. Modulate stem cells. | HOXA9, miR-137, HOXA13. | [82,83,84,85] |
| GAS5 | Tumor suppressive. Down-regulated in cancer. | Reverse EMT, inhibit metastasis and increase drug sensitivity. | CDK6, miR-221/SOCS3, miR-32, miR-181c. | [86,87,88,89] |
| MEG | Tumor suppressive. Down-regulated in cancer. | Inhibit cell proliferation, migration and invasion. | c-Met, PI3K/AKT. | [90,91,92,93,94] |