Table 2.
Major circRNAs in pancreatic cancer.
| circRNA | Role in Pancreatic Cancer | Functions | Related miRNA and Signaling | Ref. |
|---|---|---|---|---|
| ciRS-7 | Oncogenic. Up-regulated in cancer. |
Promote cell proliferation and invasion. | Sponge miR-7. Regulate EGFR and STAT3. |
[110] |
| circEIF6 | Oncogenic. Up-regulated in cancer. |
Promote cell proliferation and inhibit apoptosis. | Sponge miR-557. Regulate SLC7A11 and PI3K/AKT. | [111] |
| circFOXK2 | Oncogenic. Up-regulated in cancer. |
Promote cell proliferation, migration and invasion. | Sponge miR-942. Regulate ANK1, GDNF, PAX6, NUF2 and PDXK | [112] |
| circBFAR | Oncogenic. Up-regulated in cancer. |
Promote cell proliferation and motility. | Sponge miR-34b-5p. Regulate MET/PI3K/Akt. |
[113] |
| circ-ASH2L | Oncogenic. Up-regulated in cancer. |
Induce cell proliferation, tumor invasion and angiogenesis. | Sponge miR-34a. Regulate Notch 1. |
[114] |
| circRHOT1 | Oncogenic. Up-regulated in cancer. |
Promote cell proliferation, migration and invasion. | Sponge miR-125a, miR-330, miR-26b and miR-382. Regulate E2F3. |
[115,116] |
| circRNA_100782 | Oncogenic. Up-regulated in cancer. |
Promote cell proliferation and tumor growth. | Sponge miR-124. Regulate IL6 and STAT3. |
[117] |
| hsa_circ_0071036 | Oncogenic. Up-regulated in cancer. |
Promote cell proliferation, invasion and tumor growth. | Sponge miR-489. | [118] |
| hsa_circ_0007534 | Oncogenic. Up-regulated in cancer. |
Inhibit apoptosis. | Sponge miR-625 and miR-892b. Regulate Bcl-2 and caspase-3. |
[119] |
| circNFIB1 | Tumor suppressor. Down-regulated in cancer. | Inhibit lymph node metastasis. | Sponge miR-486-5p. Regulate PIK3R1 and VEGF-C. |
[120] |
| hsa_circ_001587 | Tumor suppressor. Down-regulated in cancer. | Inhibit cell proliferation, migration, invasion and angiogenesis. | Sponge miR-223. Regulate SLC4A4, MMP-2, MMP-9, MCM2 and VEGF. |
[121] |