Figure 3.
Glymphatic flow is driven by the cardiac cycle. Left: Two-photon imaging in live mice through a cranial window after cisterna magna injection of fluorescent microspheres. Graphs show the velocity (measured as the root-mean-square) in blue, ECG in red, blood pressure in pink, and respiration in green. Right: Surface plot visualising the how the peak traced particle velocity (Vrms, in blue) in the perivascular space closely follows the R peak of the electrocardiogram (in red), and to lesser extent ventilation pattern (in green). This suggest that the cardiac cycle is a powerful driver of perivascular flow. (Adapted from Mestre et al (2018), Nature Communications, Figure 3 and Supplementary movie 3. Reprinted under Creative Commons CC BY 4.0 licence).