Table 1.
Results of systematic review analysis on VI-RADS score performance and reproducibility.
| Authors | Study type | Number of patients included | VI-RADS threshold evaluated | Sensitivity per threshold (%) | Specificity per threshold (%) | AUC for chosen threshold | Reference standard | Interreader agreement |
|---|---|---|---|---|---|---|---|---|
| Ueno et al.15 | Retrospective | 74 | ⩾3 ⩾4 |
88 76 |
77 93 |
0.90 (pooled) | TURBT | ICC 0.85 |
| Yoshida et al.25 | Retrospective | 115 | ⩾2 | NA* | 0.83 (T2WI), 0.88 (DWI), 0.84 (DCE) | |||
| Wang et al.17 | Retrospective | 340 | ⩾3 | 87 | 96.5 | 0.94 | TURBT, PC, RC | K 0.92 |
| Kim19 | Retrospective | 297 | ⩾3 | 95 | 44 | NA | TURBT, PC, RC | K 0.89 (T2WI), 0.82 (DWI), 0.85 (DCE) |
| Barchetti et al.20 | Retrospective | 75 | ⩾3 | R1: 90.9, R2: 81.8† | R1: 88.7, R2:84.9† | R1: 0.926, R2: 0.873† | TURBT | K 0.731 |
| Hong et al.26 | Retrospective | 66 | ⩾3 | 90 | 100 | 0.95 | TURBT, RC | ICC 0.979 |
| Liu et al.21 | Retrospective | 126 | ⩾4 | 94 | 92.1 | 0.966 | TURBT, RC | NA |
| Ueno et al.16 | Retrospective | 91 | ⩾4 | 74.1 | 94.1 | 0.87 (pooled Exp.) | TURBT, RC | K 0.67 (Inexp), K 0.75 (Exp versus Inexp) |
| Vaz and Zaparolli22 | Retrospective | 30 | ⩾3 | 100 | 77.2% | 0.9675 (pooled) | TURBT | NA |
| Wang et al.18 | Retrospective | 220 | ⩾3 ⩾4 |
97.3 82.3 |
77.6 95.3 |
0.960 (pooled) | TURBT, PC, RC | NA |
| Sakamoto et al.23 | Retrospective | 176 | ⩾3 ⩾4 |
78 63 |
70 96 |
0.86 (pooled) | TURBT | K 0.43 |
| Arita et al.24 | Retrospective | 66 | ⩾3 | (82.4–94.1) | (83.7, 89.8) | (0.89–0.94) | TURBT | K (0.81–0.91) |
| Makboul et al.27 | Prospective | 50 | ⩾3 | 78 | 88 | 0.83 | TURBT | K 0.87 |
| Del Giudice et al.28 | Prospective | 231 | ⩾3 | 91.9 | 91.1 | 0.94 | TURBT, RC | K 0.92 |
| Marchioni et al.29 | Prospective | 38 (68) | ⩾4 | 85.7 | 86.9 | 0.90 (pooled) | TURBT | ICC 0.76 |
| Del Giudice et al.30 | Prospective | 149 | ⩾4 | 90.2 | 98.1 | 0.94 | TURBT, RC | K 0.89 |
| Metwally et al.31 | Prospective | 331 | >3 | 84.1 | 92.3 | 87.9 | TURBT | K 0.93 |
(Pooled): AUC provided were the result of a calculation of the overall score performance and not for the designated threshold.
*
Sensibility and specificity where not available, however negative predictive values for subsequent acquisition were 95% for T2W, 95% for DWI, and 94% for DCE.
†
R1 Reader 1; R2 Reader 2
AUC, area under the curve; Exp, experienced; ICC, intraclass correlation; Inexp, inexperienced; K, kappa; NA, Non-available; PC, Partial cystectomy; RC, Radical cystectomy; TURBT, Trans-urethral resection of bladder tumour; VI-RADS, vesical imaging-reporting and data system.