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. 2021 Jul 30;11(8):1379. doi: 10.3390/diagnostics11081379

Figure 1.

Figure 1

Adrenal and gonadal steroidogenic pathway. Blue area—common pathways for adrenals and gonads, cream area—observed only in the adrenal gland, orange area—observed only in the gonads, red zone—alternative pathway «backdoor pathway»; * under normal conditions 17hydroxyprogesterone is not a preferred substrate of 17αhydroxylase; ** different types of 17βHSD depending on the tissue in which it is expressed, testicle—17βHSD3, adrenal cortex—17βHSD5; abbreviation: StAR—steroidogenic acute regulatory protein; CYP11A1—cholesterol side-chain cleavage enzyme; HSD3B2—3βhydroxysteroid dehydrogenase 2; CYP17A1—17hydroxylase/17,20lyase; CYP21A2—21αhydroxylase; POR—cytochromeP450 oxydoreductase; B5—b5 cytochrome; ADR—adrenodoxin reductase; adrenodoxin—Adx; HSD17B—17βhydroxysteroid dehydrogenase; CYP11B2—aldosterone synthase; CYP11B1—11β-hydroxylase; CYP19A1—aromatase; SRD5A1—5αreductase 1; SRD5A2—5α reductase 2 [3,4,12].