Table 2.
Univariate and multivariate Cox proportional hazards regression models evaluating PNI, ALBI grade, and other risk factors.
| Analysis | Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|---|
| Covariate | HR | 95% CI | p-Value | HR | 95% CI | p-Value | |
| ALBI grade | 1 | Reference | Reference | ||||
| 2 | 2.6 | 1.3–5.3 | 0.010 | 2.2 | 1.0–4.7 | 0.053 | |
| 3 | 7.3 | 3.5–15.3 | <0.001 | 3.8 | 1.6–8.9 | <0.001 | |
| PNI class | 0 | Reference | Reference | ||||
| 1 | 2.7 | 2.0–3.5 | <0.001 | 2.0 | 1.4–2.9 | <0.001 | |
| Age | ≥70 years | 1.0 | 0.8–1.3 | 0.960 | |||
| AFP | >400 ng/mL | 0.9 | 0.7–1.2 | 0.620 | |||
| AST level | >31 U/L | 2.0 | 1.1–3.7 | 0.025 | 1.6 | 0.9–3.0 | 0.136 |
| ALT level | ≥35 U/L | 1.2 | 0.9–1.6 | 0.200 | |||
| INR level | >1.2 | 1.1 | 0.8–1.5 | 0.460 | |||
| Platelet count | <150/nL | 1.3 | 0.9–1.7 | 0.140 | |||
| Tumor number | ≥2 | 1.5 | 1.0–2.1 | 0.027 | 1.2 | 0.8–1.7 | 0.423 |
| Max. lesion size | >5.0 cm | 1.3 | 1.0–1.7 | 0.058 | |||
AFP, alpha fetoprotein. AST, aspartate aminotransferase. ALT, alanine aminotransferase.