. 2021 Aug 25;20:15330338211038488. doi: 10.1177/15330338211038488

Table 3.

The Regulatory Patterns of LncRNAs in Lung Cancer Metastasis.

LncRNA	Cancer type	Expression	Model	Hallmark	Molecular mechanism	Function	Reference
TNK2-AS1	NSCLC	Up	Vitro	Angiogenesis	Interacts with STAT3 to upregulate VEGFA expression	Promotes angiogenesis and metastasis	Wang et al¹¹⁷
LOC100132354	LAD	Up	Vitro	Angiogenesis	Activates VEGFA/VEGFR2 pathway	Promotes angiogenesis and metastasis	Wang et al¹¹⁸
LINC00667	NSCLC	Up	Vitro and vivo	Angiogenesis	Stabilizes VEGFA mRNA by EIF4A3	Promotes angiogenesis and metastasis	Yang et al¹¹⁹
Lnc-EPIC1	NSCLC	Up	Vitro and vivo	Angiogenesis	Activates Ang2/Tie2 pathway	Promotes angiogenesis and metastasis	Hou et al¹²⁰
LCPAT1	NSCLC	Up	Vitro	Autophagy	Promotes smoking and PM-2.5-joint induced autophagy	Promotes autophagy and metastasis	Lin et al¹²¹
Loc146880	LAD	Up	Vitro	Autophagy	PM-2.5 induce ROS production to elevate its expression Promotes PM-2.5-induced autophagy	Promotes autophagy and metastasis	Deng et al¹²²
TSLNC8	NSCLC	Down	Vitro	Autophagy	Inhibits STAT3/HIF-1α pathway	Inhibits autophagy and metastasis	Fan et al¹²³
IGFBP4-1	NSCLC	Up	Vitro	Aerobic glycolysis	Increasing the expression of HK2	Promotes glycolysis and metastasis	Yang et al¹²⁴
AC020978	NSCLC	Up	Vitro	Aerobic glycolysis	Prevents PKM2 from ubiquitin-mediated degradation and increases PKM2-enhanced HIF-1α transcription activity	Promotes glycolysis and metastasis	Hua et al¹²⁵
LINC01537	NSCLC	Down	Vitro	Aerobic glycolysis	Inhibits PGK1 expression by targeting PDE2A	Inhibits glycolysis and metastasis	Gong et al¹²⁶
NEAT1	NSCLC	Up	Vitro and vivo	Immune escape	Downregulates tumor-infiltration cytotoxic T cells through cGAS/STING/IFN pathway	Promotes immune escape and metastasis	Ma et al¹²⁷ and Chen et al¹²⁸
NKILA	NSCLC	Up	Vitro and vivo	Immune escape	Promotes AICD of CTLs via NF-κB pathway	Promotes immune escape and metastasis	Huang et al¹²⁹
HOTAIRM1	LAD	Down	Vitro and vivo	Immune escape	Inhibits immunosuppressive activity of MDSCs	Inhibits immune escape and metastasis	Tian et al¹³⁰ and Chen et al¹³¹

Abbreviations: AICD, activation-induced cell death; Ang2, angiopoietin 2; cGAS, cyclic GMP-AMP synthase; CTL, cytotoxic T lymphocyte; EIF4A3, eukaryotic translation initiation factor 4A3; HIF-1α, hypoxia-inducible factor-1α; HK2, hexokinase 2; HOTAIR, HOX transcript antisense intergenic RNA; HOTAIRM1, HOTAIR myeloid-specific 1; IFN, interferon; IGFBP4-1, insulin-like growth factor binding protein 4 to 1; LAD, lung adenocarcinoma; LCPAT1, lung cancer progression-associated transcript 1; Lnc-EPIC1, long noncoding RNA EPIC1; MDSC, myeloid-derived suppressor cell; lncRNA, long noncoding RNA; mRNA, messenger RNA; NEAT1, nuclear paraspeckle assembly transcript 1; NF-κB, nuclear factor kappa B; NKILA, NF-κB interacting lncRNA; NSCLC, nonsmall cell lung cancer; PDE2A; phosphodiesterase 2A; PGK1, phosphoglycerate kinase 1; PKM2, M2 isoform of pyruvate kinase; PM-2.5, particulate matter-2.5; ROS, reactive oxygen species; STAT3, signal transducer and activator of transcription 3; STING, stimulator of interferon gene; TNK2-AS1, tyrosine kinase nonreceptor 2 antisense RNA 1; TSLNC8, tumor-suppressive role of lncRNA on chromosome 8p12; VEGFA, vascular endothelial growth factor A; VEGFR2, vascular endothelial growth factor receptor 2.