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. 2021 Aug 2;10(8):1964. doi: 10.3390/cells10081964

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Local NGF therapy of GUs in aging rats increases angiogenesis, accelerates gastric ulcer healing, and improves the quality of mucosal regeneration. In aging rats, either PBS (control) or NGF (100 μg/kg body weight in 200 μL PBS) was locally injected to the ulcer base after GU induction. Mucosal blood flow, microvessel density, GU size, and mucosal regeneration were examined 3 weeks after GU induction. Local NGF treatment of GUs in aging rats (A) significantly increased mucosal blood flow in GU scars/margins by 37% compared to the control, and (B) increased vascular density in granulation tissue at the base of the GU scar/margin by 62% compared to the control, both showing increased angiogenesis. (C) NGF therapy accelerated GU healing, as reflected by the >5-fold reduction in GU size. (D) Mucosal histology showed better regeneration of gastric mucosa in GU scars of NGF-treated rats compared to the poor, disorganized, and abnormal regeneration (e.g., large, dilated, irregular abnormal glands) in the control group (reprinted with permission from [96]).