Table 1.
Table summarizing the identified parasite-derived proteins with suspected pro-carcinogenic activity. BLCA, bladder cancer; CC, cholangiocarcinoma; CRC, colorectal carcinoma; HCC, hepatocellular carcinoma; SCC, squamous cell carcinoma.
| Molecule | Effect | Type of Cancer Associated with Infection | Expressing Lifecycle Stage |
Reference (PMID) |
|---|---|---|---|---|
| Opisthorchis viverrini | ||||
| Granulin (Ov-GRN-1) |
angiogenesis | eggs, metacercariae, juveniles, adults | 25450776 | |
| wound healing | CC | 26485648 | ||
| proliferation | 19816559 | |||
| Clonorchis sinensis | ||||
| CsGRN | cell migration and invasion |
CC, HCC | adults | 28545547 |
| Csseverin | anti-apoptotic | metacercariae and adults | 24367717 | |
| Schistosoma haematobium | ||||
| IPSE/α1 | proliferation and angiogenesis |
BLCA, SCC | eggs only | 33101456 |
| Schistosoma mansoni | ||||
| IPSE/α1 | proliferation, c-Jun and STAT3 activation |
HCC | eggs only | 30053321 |
| CRC | 33361772 | |||